Research

Laboratory of Neurobiology for Translational Medicine

The neurobiology laboratory for translational medicine supports the clinic from a biochemical, genetic and molecular point of view , collecting as much data as possible from the same patient in order to better characterize him or her by adding the molecular aspect to the clinical picture.

The laboratory is equipped for biochemical analyses (Western blot, immunoprecipitation, protein expression, bioinformatics), immunohistochemical analyses (fluorescence) and collaborates closely with research groups with which it performs mass spectrometry and genetic analyses (rtPCR, PCR, sequencing).

Activities

The main activity concerns the analysis of human samples from blood samples taken from patients affected by central nervous system (CNS) diseases such as ischemia , amyotrophic lateral sclerosis (ALS), Alzheimer's and Parkinson's disease, on which the molecular, genetic and proteomic mechanisms that can vary both during the onset and development of the diseases are investigated .

The laboratory is mainly focused on the identification of new diagnostic and prognostic biomarkers of neurological pathologies , and in addition it studies how a rehabilitation path can create biomolecular changes through the search for potential rehabilitation biomarkers.

In the context of what is now called “ personalized medicine ”, our goal is to be able to identify a biological imprint of CNS pathologies that will help improve diagnosis , pharmacological research and even rehabilitation.

For the experimental analyses, biological samples mainly coming from the internal institutional Biobank are used , which allows to compare the results obtained experimentally with the clinical ones noted during the collection of the biological sample.