Research
Laboratory of Neurobiology for Translational Medicine
The neurobiology laboratory for translational medicine supports the clinic from a biochemical, genetic and molecular point of view, collecting as much data as possible from the same patient in order to better characterize him/her by adding the molecular aspect to the clinical picture.
The laboratory is equipped for biochemical analyses (western blot, immunoprecipitations, protein expression, bioinformatics), immunohistochemical analyses (fluorescence) and collaborates closely with research groups with which it carries out mass spectrometry and genetic analyses (rtPCR, PCR, Sequencing).
Activities
The main activity concerns the analysis of human samples from blood samples of patients affected by central nervous system (CNS) diseases such as Ischemia, amyotrophic lateral sclerosis (ALS), Alzheimer's and Parkinson's, on which the molecular, genetic and proteomic mechanisms that can vary both during the onset and development of the diseases are investigated.
Fluorescence Microscope, Nikon Eclipse Ti2-E
The laboratory is mainly focused on the identification of new diagnostic and prognostic biomarkers of neurological pathologies, and in addition it studies how a rehabilitation path can create biomolecular modifications through the search for potential rehabilitation biomarkers.
Operator preparing a gel electrophoresis experiment
In the context of what is now called “personalized medicine”, our goal is to be able to identify a “biological fingerprint” of CNS pathologies that helps improve diagnosis, pharmacological research and even rehabilitation.
Isolated human blood cells (PBMC) with double antibody labeling (green and red) and DAPI staining
For the experimental analyses, biological samples coming from the internal institutional Biobank are mainly used, which allows to compare the experimentally obtained results with the clinical ones noted during the collection of the biological sample.
Team
Laboratory Manager:
Marco Feligioni, PhD
Laboratory contacts:
Pamela Cappelletti, PhD
Mary The Judge
Dr. Melania Filareti, Biologist
